Crop Sac Stimulating Activity and Mammary Inhibition Produced by a Human Placental Protein

C. E. Castillo; F. Beas

doi:10.1055/s-0028-1093978

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1973; 5(2): 129-133
DOI: 10.1055/s-0028-1093978

Originals

Crop Sac Stimulating Activity and Mammary Inhibition Produced by a Human Placental Protein[*]

C. E. Castillo [**] , F. Beas [***]

Laboratory for Pediatric Research, Department of Mother and Child Health, School of Medicine, University of Chile, Santiago, Chile

Abstract

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Abstract

A protein obtained from human term placentas evoked crop sac stimulation in pigeons, both by local and systemic injection. A dose-response curve was determined for this action. In spite of these findings, this protein inhibited the mammary growth produced by estradiol and progesterone in castrated rats as evaluated by observation of whole mounts and histological sections of the glands and by dry fefatted tissue weighings and nuclei acids analysis.

Key words

Crop Sac Stimulation Activity - Mammary Gland Growth Inhibition - Human Placental Protein

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References

1 This work was partly supported by Comisión Nacional Investigación Cientifica y Tecnológica, Chile y Comisión Investigación Científica, Universidad de Chile

2 Holder of a fellowship from Comisión Nacional de Investigación Cientifica y Tecnológica.

3 Present address: Casilla 5370, Santiago 3, Chile.